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The series tells the story of Alex Drake (played by Keeley Hawes), a police officer in service with the London Metropolitan Police, who is shot in 2008 by a man called Arthur Layton and inexplicably regains consciousness in 1981.

Brit Karl Pilkington has led a sheltered life. Not having done any traveling, he enjoys living within the comforts of what he knows, basically that being what is purely British. As such, his friends, Ricky Gervais and Stephen Merchant, decide to send Karl to various parts of the world to experience unfamiliar cultures. Stephen believes that travel is a life broadening venture, and hopes that Karl will indeed feel like his life is enriched by these travels. Ricky, however, hopes that Karl will hate every minute of his travels. For Ricky, this experiment is the most expensive gag for his own pleasure that he could have conceived.

The Doctor is a renegade Time Lord: an eccentric, highly-intelligent scientist from a distant planet. He travels through time and space in the TARDIS, a curious device, larger on the inside than on the outside, which was designed to change its appearance to suit its surroundings. Unfortunately, the Doctor's TARDIS seems to be broken, and always appears as a blue British police box. The Doctor has a soft spot for the planet Earth, and often visits there, either to save it from various alien threats or to whisk a choice few inhabitants away to the distant parts of the galaxy to help him fight evil there. The Doctor has many foes, including Daleks (led by Davros), and The Master, another renegade Time Lord. Time Lord biology enables them to regenerate their bodies, and so both the Doctor and the Master appear to evolve over the years...

Rick Grimes is a former Sheriff's deputy who has been in a coma for several months after being shot while on duty. When he awakens he discovers that the world has been ravished by a zombie epidemic of apocalyptic proportions, and that he seems to be the only person still alive. After returning home to discover his wife and son missing, he heads for Atlanta to search for his family. Narrowly escaping death at the hands of the zombies on arrival in Atlanta he is aided by another survivor, Glenn, who takes Rick to a camp outside the town. There Rick finds his wife Lori and his son, Carl, along with his partner/best friend Shane and a small group of survivors who struggle to fend off the zombie hordes; as well as competing with other surviving groups who are prepared to do whatever it takes to survive in this harsh new world.